HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-4,6-bis(morpholin-4-yl)-1,3,5-triazine → 4-(4,6-Dimorpholino-1,3,5-triazin-2-yl)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-4,6-bis(morpholin-4-yl)-1,3,5-triazine | HCID 224967 | — |
| Reactant | 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile | HCID 2734625 | — |
| Solvent | Ethyl acetate hexane | HCID 21226206 | — |
| Product | 4-(4,6-Dimorpholino-1,3,5-triazin-2-yl)benzonitrile | HCID 58507720 | 40% |
Reaction Steps
Following the general procedure A, 4,4′-(6-chloro-1,3,5-triazine-2,4-diyl)dimorpholine was coupled with 4-cyanophenylboronic acid pinacol ester with reaction time of 15 h. Chromatography (hexane/ethyl acetate 1:1) gave the 40% of the title compound as a colorless solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08921361B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-0f4c68454d6b4ba9973d2243d038a6a9 |
| Source note | uspto-grants-2014_12 |