2-Chloro-4,6-bis(morpholin-4-yl)-1,3,5-triazine → HCID 58507795, compound

HRID 1408444Notes

Reaction equation

HRID 1408444 reaction equation
Cl[C:2]1[N:7]=[C:6]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)[N:5]=[C:4]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)[N:3]=1.[N:20]1([C:26]2[N:31]=[CH:30][C:29](B3OC(C)(C)C(C)(C)O3)=[CH:28][CH:27]=2)[CH2:25][CH2:24][O:23][CH2:22][CH2:21]1>CCCCCC.C(OCC)(=O)C>[O:23]1[CH2:24][CH2:25][N:20]([C:26]2[N:31]=[CH:30][C:29]([C:2]3[N:7]=[C:6]([N:8]4[CH2:13][CH2:12][O:11][CH2:10][CH2:9]4)[N:5]=[C:4]([N:14]4[CH2:19][CH2:18][O:17][CH2:16][CH2:15]4)[N:3]=3)=[CH:28][CH:27]=2)[CH2:21][CH2:22]1

Participants

4

Reactant 2

HCID 2249672-Chloro-4,6-bis(morpholin-4-yl)-1,3,5-triazineHCID 27953634-(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl)morpholine

Product 1

HCID 58507795HCID 58507795, compound

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

Following the general procedure A, 4,4′-(6-chloro-1,3,5-triazine-2,4-diyl)dimorpholine was coupled with 6-(morpholin-4-yl)pyridine-3-boronic acid pinacol ester acid pinacol ester with reaction time of 15 h. Chromatography (hexane/ethyl acetate 1:1) gave the title compound as a colorless solid.

Sources & evidence

ORD record
ord-5aa3f22c0f304fecac2395fd6fb471f8
Source dataset
uspto-grants-2014_12
Patent number
US08921361B2

Reaction notes

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