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2-Chloro-4,6-bis(morpholin-4-yl)-1,3,5-triazine → Bimiralisib
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Chloro-4,6-bis(morpholin-4-yl)-1,3,5-triazine | HCID 224967 | — |
| 反応物 | 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)pyridin-2-amine | HCID 57416499 | — |
| 溶媒 | Dichloromethane methanol | HCID 21226129 | — |
| 生成物 | Bimiralisib | HCID 58507717 | — |
反応手順
Following the general procedure A, 4,4′-(6-chloro-1,3,5-triazine-2,4-diyl)dimorpholine was coupled with 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)pyridin-2-amine with reaction time of 15 h. Chromatography (dichlormethane/methanol 97:3) gave the title compound as an colorless oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08921361B2 |
| 出典データセット | uspto-grants-2014_12 |
| ORD ID | ord-a08160f18823491a94ccbddc85ff3a3a |
| 出典メモ | uspto-grants-2014_12 |