1-Methylpiperazine → HCID 58507964, compound

HRID 1408459Notes

Reaction equation

HRID 1408459 reaction equation
Cl[C:2]1[N:7]=[C:6]([Cl:8])[N:5]=[C:4]([N:9]2[CH2:14][CH2:13][O:12][CH2:11][CH2:10]2)[N:3]=1.[CH3:15][N:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1>ClCCl>[Cl:8][C:6]1[N:7]=[C:2]([N:19]2[CH2:20][CH2:21][N:16]([CH3:15])[CH2:17][CH2:18]2)[N:3]=[C:4]([N:9]2[CH2:14][CH2:13][O:12][CH2:11][CH2:10]2)[N:5]=1

Participants

4

Reactant 2

HCID 531671-MethylpiperazineHCID 810762,4-Dichloro-6-morpholino-1,3,5-triazine

Product 1

HCID 58507964HCID 58507964, compoundYield 39%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

4-(4,6-dichloro-1,3,5-triazin-2-yl)morpholine (1.40 g, 5.96 mmol, 1.0 eq.) was dissolved in dichloromethane (21 ml). N-Methylpiperazine (727 μl, 6.56 mmol, 1.1 eq.) was added to the reaction mixture at 0° C. and stirred for 30 minutes at the same temperature. The solvent was evaporated under reduced pressure and purification by flash chromatography yielded the title compound as a white solid (690 mg, 39%).

Workup

  1. customThe solvent was evaporated under reduced pressure and purification by flash chromatography

Sources & evidence

ORD record
ord-61bbbf8ccc2742ad99f3da63e94b235a
Source dataset
uspto-grants-2014_12
Patent number
US08921361B2

Reaction notes

Loading…