Methanol → HCID 58507693, compound

HRID 1408465Notes

Reaction equation

HRID 1408465 reaction equation
[Si:1]([O:8][C:9]1[CH:10]=[C:11]([C:15]2[N:16]=[C:17]([N:34]3[CH2:39][CH2:38][O:37][CH2:36][CH2:35]3)[C:18]3[S:23][C:22]([CH2:24][CH2:25][NH:26]C(=O)OC(C)(C)C)=[CH:21][C:19]=3[N:20]=2)[CH:12]=[CH:13][CH:14]=1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].C(Cl)Cl.CO>C(O)(C(F)(F)F)=O.C(Cl)Cl>[Si:1]([O:8][C:9]1[CH:10]=[C:11]([C:15]2[N:16]=[C:17]([N:34]3[CH2:35][CH2:36][O:37][CH2:38][CH2:39]3)[C:18]3[S:23][C:22]([CH2:24][CH2:25][NH2:26])=[CH:21][C:19]=3[N:20]=2)[CH:12]=[CH:13][CH:14]=1)([C:4]([CH3:6])([CH3:7])[CH3:5])([CH3:3])[CH3:2]

Participants

5

Reactant 3

HCID 887MethanolHCID 6344DichloromethaneHCID 58507731HCID 58507731, compound

Product 1

HCID 58507693HCID 58507693, compound

Reagents, catalysts & solvents 1

HCID 21863450Trifluoroacetic acid methylene chlorideSolvent

Procedure

tert-butyl 2-(2-(3-(tert-butyldimethylsilyloxy)phenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)ethylcarbamate (10.0 mg, 1.0 eq.) was solved in 3 ml of TFA:DCM (1:1). The reaction mixture was stirred at room temperature for 2 h. The silica column chromatography (DCM:MeOH/95:5) gave the title compound.

Sources & evidence

ORD record
ord-27cb6ccf2ac34710901134b6955a57ef
Source dataset
uspto-grants-2014_12
Patent number
US08921361B2

Reaction notes

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