反应详情

Methyl 3-[(dipropylamino)carbonyl]-5-(1,3-thiazol-2-yl)benzoate (4.4 g, 12.8 mmol) is dissolved in 1:1:1 tetrahydrofuran/methanol/water (60 mL), and lithium hydroxide monohydrate is added (1.1 g, 25.6 mmol). The reaction is stirred 15 min and is concentrated under reduced pressure. The residue is diluted in chloroform and washed with water, brine, dried (magnesium sulfate), filtered, and concentrated under reduced pressure to give the title compound. ESI MS m/z 333.1 [M+H]+.

1. additionis added (1.1 g, 25.6 mmol)
2. concentrationis concentrated under reduced pressure
3. additionThe residue is diluted in chloroform
4. washwashed with water, brine
5. dry with materialdried (magnesium sulfate)
6. filtrationfiltered
7. concentrationconcentrated under reduced pressure