反应详情

To a mixture of 6-bromo-2-phenyl-2′-thioxospiro[chroman-4,4′-imidazolidin]-5′-one (300 mg, 0.77 mmol) and K2CO3 (427 mg, 3.1 mmol) in CH3CN (6 mL) was added PrBr (380 mg, 3.1 mmol). The reaction mixture was refluxed for 2 h. The mixture was filtered, and the filtrate was concentrated to give a residue, which was purified by preparative TLC to give 6-bromo-2-phenyl-1′-propyl-2′-(propylthio)spiro[chroman-4,4′-imidazol]-5′(1′H)-one (285 mg, 90%). 1H-NMR (CDCl3): 0.87 (m, 3H), 1.00 (m, 3H), 1.64 (m, 2H), 1.73 (m, 2H), 1.89 (m, 1H), 2.48 (m, 1H), 3.16 (m, 2H), 3.44 (m, 2H), 5.82 (m, 1H), 6.81 (m, 2H), 7.22 (m, 1H), 7.30 (m, 3H), 7.48 (m, 2H).

1. temperatureThe reaction mixture was refluxed for 2 h
2. filtrationThe mixture was filtered
3. concentrationthe filtrate was concentrated
4. customto give a residue, which
5. customwas purified by preparative TLC