反应详情

To a mixture of 6-bromo-2-phenyl-2′-thioxospiro[chroman-4,4′-imidazolidin]-5′-one (131 mg, 0.34 mmol) and K2CO3 (186 mg, 1.35 mmol) in CH3CN (5 mL) was added PrBr (166 mg, 1.35 mmol). The reaction mixture was refluxed for 2 h. The mixture was filtered, and the filtrate was concentrated to give a residue, which was purified by preparative TLC to give (2R,4S)-6-bromo-2-phenyl-1′-propyl-2′-(propylthio)spiro[chroman-4,4′-imidazol]-5′(1′H)-one (75 mg, 47%).

1. temperatureThe reaction mixture was refluxed for 2 h
2. filtrationThe mixture was filtered
3. concentrationthe filtrate was concentrated
4. customto give a residue, which
5. customwas purified by preparative TLC