反应详情

温度

120 °C

To a solution of 1′-benzyl-2′-(benzylthio)-6-bromo-2-phenylspiro[chroman-4,4′-imidazol]-5′(1′H)-one (60 mg, 0.10 mmol) in MeOH/EtOH (1:1, 2 mL) in a 10 mL CEM microwave test tube is added NH4I (50 mg, 0.34 mmol) and NH3/MeOH (7 N, 2 mL). The resulting mixture is heated in a CEM microwave reactor at 120° C. for 60 min. The cooled mixture is concentrated in vacuo and the residue is purified by a reversed HPLC to give 2′-amino-1′-benzyl-6-bromo-2-phenylspiro[chroman-4,4′-imidazol]-5′(1′H)-one (17.3 mg, 34%) as a TFA salt. MS m/z 462 (M+H+).

1. concentrationThe cooled mixture is concentrated in vacuo
2. customthe residue is purified by a reversed HPLC