HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 2,2,2-Trifluoroethyl trifluoromethanesulfonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | 2,2,2-Trifluoroethanol | HCID 6409 | — |
| Reactant | Trifluoromethanesulfonic anhydride | HCID 67749 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2,2,2-Trifluoroethyl trifluoromethanesulfonate | HCID 80366 | — |
Reaction Steps
Combine 2,2,2-trifluoro-ethanol (6.2 mL), pyridine (6.8 mL) and CH2Cl2 (20 mL) cooled in an ice bath. Add Tf2O (25 g) over about 45 minutes. After 15 minutes, add water, separate the layers and extract with water. The organic layer was dried over Na2SO4 and concentrated through a short path distillation apparatus (8 g, 54%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08921359B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-86a1565051a340ccb3735e038f322d85 |
| Source note | uspto-grants-2014_12 |