反应详情

Combine 2,2,2-trifluoro-ethanol (6.2 mL), pyridine (6.8 mL) and CH2Cl2 (20 mL) cooled in an ice bath. Add Tf2O (25 g) over about 45 minutes. After 15 minutes, add water, separate the layers and extract with water. The organic layer was dried over Na2SO4 and concentrated through a short path distillation apparatus (8 g, 54%).

1. customseparate the layers
2. extractionextract with water
3. dry with materialThe organic layer was dried over Na2SO4
4. concentrationconcentrated through a short path distillation apparatus (8 g, 54%)