Water → HCID 178481310, compound

HRID 1408823Notes

Reaction equation

HRID 1408823 reaction equation
OC(C(F)(F)F)=O.Br[C:9]1[CH:10]=[C:11]2[C:18]3([CH2:23][C:22](=[O:24])[N:21]([CH3:25])[C:20](=[NH:26])[NH:19]3)[CH2:17][CH:16]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)[O:15][C:12]2=[CH:13][CH:14]=1.[N:33]1[CH:38]=[CH:37][CH:36]=[C:35](B(O)O)[CH:34]=1.C([O-])([O-])=O.[Cs+].[Cs+].O>O1CCOCC1>[NH:26]=[C:20]1[NH:19][C:18]2([C:11]3[C:12](=[CH:13][CH:14]=[C:9]([C:35]4[CH:34]=[N:33][CH:38]=[CH:37][CH:36]=4)[CH:10]=3)[O:15][CH:16]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)[CH2:17]2)[CH2:23][C:22](=[O:24])[N:21]1[CH3:25]

Participants

6

Reactant 4

HCID 962WaterHCID 10796Cesium carbonateHCID 27343783-Pyridinylboronic acidHCID 178481309HCID 178481309, compound

Product 1

HCID 178481310HCID 178481310, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a solution of 6-bromo-2′-imino-1′-methyl-2-phenyl-2′,3′-dihydro-1′H-spiro[chroman-4,4′-pyrimidin]-6′(5′H)-one TFA salt (12 mg, 0.023 mmol) and pyridin-3-ylboronic acid (9 mg, 0.070 mmol) in 1,4-dioxane (3 mL) charged in a 10-mL microwave test tube is added Cs2CO3 (63 mg, 0.195 mmol) and H2O (0.5 mL), followed by

Sources & evidence

ORD record
ord-8eb7afd876e64f98bbd1c568abc28d91
Source dataset
uspto-grants-2014_12
Patent number
US08921359B2

Reaction notes

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