Hydrochloric Acid → HCID 86684762, compound

Participants

Reaction Steps

A solution of 109 (0.70 g, 1.67 mmol) in dichloromethane (4.0 mL) and methanol (1.0 mL) was treated at room temperature with 4 mol/L HCl in dioxane (2.5 mL) in a closed vessel for 16 hrs. The resulting suspension was stirred with ether (10 mL). The solid precipitate was collected on filter paper and washed several times with ether to afford a tan solid 110 (95% yield) which was confirmed by LC/MS and used directly for the next step.

Provenance & Evidence