Hydrochloric Acid → HCID 86684762, compound

HRID 1408895Notes

Reaction equation

HRID 1408895 reaction equation
CC1(C)[O:6][C@H:5]([CH2:7][C:8]2[CH:9]=[C:10]([F:29])[C:11]([N:14]3[CH2:20][CH:19]4[N:21](C(OC(C)(C)C)=O)[CH:16]([CH2:17][CH2:18]4)[CH2:15]3)=[N:12][CH:13]=2)[CH2:4][O:3]1.[ClH:31].CCOCC>ClCCl.CO.O1CCOCC1>[ClH:31].[ClH:31].[CH:19]12[NH:21][CH:16]([CH2:17][CH2:18]1)[CH2:15][N:14]([C:11]1[N:12]=[CH:13][C:8]([CH2:7][C@@H:5]([OH:6])[CH2:4][OH:3])=[CH:9][C:10]=1[F:29])[CH2:20]2

Participants

7

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 70652850HCID 70652850, compound

Product 1

HCID 86684762HCID 86684762, compoundYield 95%

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

A solution of 109 (0.70 g, 1.67 mmol) in dichloromethane (4.0 mL) and methanol (1.0 mL) was treated at room temperature with 4 mol/L HCl in dioxane (2.5 mL) in a closed vessel for 16 hrs. The resulting suspension was stirred with ether (10 mL). The solid precipitate was collected on filter paper and washed several times with ether to afford a tan solid 110 (95% yield) which was confirmed by LC/MS and used directly for the next step.

Workup

  1. customThe solid precipitate was collected
  2. filtrationon filter paper
  3. washwashed several times with ether

Sources & evidence

ORD record
ord-1335bd2dc9f44f26bca74608ab595c52
Source dataset
uspto-grants-2014_12
Patent number
US08921373B2

Reaction notes

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