反应详情

Methyl 3-{[(5-methoxy-2,5-dioxopentyl)amino]carbonyl}benzoate (520 mg, 1.7 mmol) is dissolved in anhydrous tetrahydrofuran (4 mL), and (methoxycarbonylsulfamoyl)triethylammonium hydroxide, inner salt (810 mg, 3.4 mmol). The reaction is microwaved (100 W, 2 min) in a sealed vessel, cooled, filtered, and concentrated under reduced pressure. Purification by flash chromatography (silica gel, 40% ethyl acetate/hexanes) gives the title compound. ESI MS m/z 290.1 [M+H]+.

1. customThe reaction is microwaved (100 W, 2 min) in a sealed vessel
2. temperaturecooled
3. filtrationfiltered
4. concentrationconcentrated under reduced pressure
5. customPurification by flash chromatography (silica gel, 40% ethyl acetate/hexanes)