Cyclopentylamine → HCID 58896840, compound

HRID 1409115Notes

Reaction equation

HRID 1409115 reaction equation
Br[C:2]1[C:7]([Cl:8])=[CH:6][N:5]=[C:4]2[NH:9][CH:10]=[CH:11][C:3]=12.[CH:12]1([NH2:17])[CH2:16][CH2:15][CH2:14][CH2:13]1>>[Cl:8][C:7]1[CH:6]=[N:5][C:4]2[NH:9][CH:10]=[CH:11][C:3]=2[C:2]=1[NH:17][CH:12]1[CH2:16][CH2:15][CH2:14][CH2:13]1

Participants

3

Reactant 2

HCID 2906CyclopentylamineHCID 468355224-Bromo-5-chloro-1H-pyrrolo[2,3-b]pyridine

Product 1

HCID 58896840HCID 58896840, compound

Conditions

Temperature
110 °C

Procedure

To 4-bromo-5-chloro-1H-pyrrolo[2,3-b]pyridine (D) was added cyclopentylamine (0.5 mL) in a sealed tube. The mixture was heated to 110° C. for 24-48 h. The mixture was concentrated. Preparative HPLC provided 5-chloro-N-cyclopentyl-1H-pyrrolo[2,3-b]pyridin-4-amine (127)(7.4 mg) as the TFA salt.

Workup

  1. concentrationThe mixture was concentrated

Sources & evidence

ORD record
ord-ad17d807e86648f0bb6d4aae90cacb00
Source dataset
uspto-grants-2014_12
Patent number
US08921376B2

Reaction notes

Loading…