HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dichloroethane → HCID 178513561, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dichloroethane | HCID 11 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 4-Bromo-5-chloro-1H-pyrrolo[2,3-b]pyridine | HCID 46835522 | — |
| Product | HCID 178513561 | HCID 178513561 | — |
Reaction Steps
To a vial with Compound D′ (0.1 mmol) in DMF (1 mL), EDC (2 equivalent, 0.2 mmol) and HOBt (0.5 equivalent, 0.05 mmol) were added and the reaction mixture was stirred at room temperature for half an hour, amine (1.2 equivalent, 0.12 mmol) was added and the reaction mixture was stirred at room temperature for 2-3 hour. Reverse phase HPLC was used to purify the final compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08921376B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-f2310ed1b88740c2b2f637a35f217648 |
| Source note | uspto-grants-2014_12 |