1,2-Dichloroethane → HCID 178513561, compound

HRID 1409117Notes

Reaction equation

HRID 1409117 reaction equation
Br[C:2]1[C:7](Cl)=[CH:6][N:5]=[C:4]2[NH:9][CH:10]=[CH:11][C:3]=12.C(Cl)CCl.[CH:16]1[CH:17]=C[C:19]2[N:24](O)N=[N:22][C:20]=2[CH:21]=1.CN(C=[O:30])C>>[N:9]1[CH:10]=[CH:11][C:3]2[C:4]=1[NH:5][CH:6]=[CH:7][C:2]=2[C:16]1[CH:21]=[C:20]([C:19]([NH2:24])=[O:30])[NH:22][CH:17]=1

Participants

5

Reactant 4

HCID 111,2-DichloroethaneHCID 6228DimethylformamideHCID 757711-HydroxybenzotriazoleHCID 468355224-Bromo-5-chloro-1H-pyrrolo[2,3-b]pyridine

Product 1

HCID 178513561HCID 178513561, compound

Procedure

To a vial with Compound D′ (0.1 mmol) in DMF (1 mL), EDC (2 equivalent, 0.2 mmol) and HOBt (0.5 equivalent, 0.05 mmol) were added and the reaction mixture was stirred at room temperature for half an hour, amine (1.2 equivalent, 0.12 mmol) was added and the reaction mixture was stirred at room temperature for 2-3 hour. Reverse phase HPLC was used to purify the final compound.

Workup

  1. stirringthe reaction mixture was stirred at room temperature for 2-3 hour
  2. customto purify the final compound

Sources & evidence

ORD record
ord-f2310ed1b88740c2b2f637a35f217648
Source dataset
uspto-grants-2014_12
Patent number
US08921376B2

Reaction notes

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