[3-(Hydroxymethyl)phenyl]boronic acid → HCID 58207118, compound

HRID 1409148Notes

Reaction equation

HRID 1409148 reaction equation
Cl[C:2]1[N:7]2[N:8]=[CH:9][CH:10]=[C:6]2[N:5]=[C:4]([NH2:11])[CH:3]=1.[OH:12][CH2:13][C:14]1[CH:15]=[C:16](B(O)O)[CH:17]=[CH:18][CH:19]=1>>[NH2:11][C:4]1[CH:3]=[C:2]([C:18]2[CH:19]=[C:14]([CH2:13][OH:12])[CH:15]=[CH:16][CH:17]=2)[N:7]2[N:8]=[CH:9][CH:10]=[C:6]2[N:5]=1

Participants

3

Reactant 2

HCID 2734662[3-(Hydroxymethyl)phenyl]boronic acidHCID 442513067-Chloropyrazolo[1,5-a]pyrimidin-5-amine

Product 1

HCID 58207118HCID 58207118, compound

Procedure

The titled compound was prepared using a procedure analogous to that described in connection with Example 15 except that 7-chloropyrazolo[1,5-a]pyrimidin-5-amine (1E) and 3-(hydroxymethyl)phenylboronic acid were used as starting materials. 1H NMR (400 MHz, MeOD) δ ppm 4.72 (s, 2H) 6.27-6.31 (m, 1H) 6.47 (s, 1H) 7.56 (t, J=7.58 Hz, 1H) 7.62 (d, J=7.58 Hz, 1H) 7.84 (d, J=7.33 Hz, 1H) 7.91-7.97 (m, 2H).

Sources & evidence

ORD record
ord-2efc50679d09471bbb9d3dd6449e6a6f
Source dataset
uspto-grants-2014_12
Patent number
US08921358B2

Reaction notes

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