2-Chloromethyl 2-(trimethylsilyl)ethyl ether → HCID 86714665, compound

HRID 1409452Notes

Reaction equation

HRID 1409452 reaction equation
[F:1][C:2]([F:15])([F:14])[CH2:3][C:4]1[NH:5][CH:6]=[C:7]([C:9]([O:11][CH2:12][CH3:13])=[O:10])[N:8]=1.[CH3:16][Si:17]([CH2:20][CH2:21][O:22][CH2:23]Cl)([CH3:19])[CH3:18]>>[F:15][C:2]([F:1])([F:14])[CH2:3][C:4]1[N:5]([CH2:23][O:22][CH2:21][CH2:20][Si:17]([CH3:19])([CH3:18])[CH3:16])[CH:6]=[C:7]([C:9]([O:11][CH2:12][CH3:13])=[O:10])[N:8]=1

Participants

3

Reactant 2

HCID 27242712-Chloromethyl 2-(trimethylsilyl)ethyl etherHCID 178469893HCID 178469893, compound

Product 1

HCID 86714665HCID 86714665, compound

Procedure

The title compound was prepared using the procedure described in Example 52(b) starting from ethyl 2-(2,2,2-trifluoroethyl)-1H-imidazole-4-carboxylate (3.6 mmol, 0.8 g) and SEM-Cl (4.3 mmol, 0.8 ml). Yield 602 mg. 1H-NMR (400 MHz; CDCl3): δ 0.01 (s, 9H), 0.91 (t, 2H), 1.39 (t, 3H), 3.48 (t, 2H), 3.75 (q, 2H), 4.39 (q, 2H), 5.33 (s, 2H), 7.69 (s, 1H).

Sources & evidence

ORD record
ord-8ff34770b00246f6bba0ed5ff32a0fb5
Source dataset
uspto-grants-2014_12
Patent number
US08921378B2

Reaction notes

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