2-Chloromethyl 2-(trimethylsilyl)ethyl ether → HCID 70981359, compound

HRID 1409456Notes

Reaction equation

HRID 1409456 reaction equation
[F:1][C:2]([F:14])([F:13])[C:3]1[NH:4][CH:5]=[C:6]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:7]=1.[CH3:15][Si:16]([CH2:19][CH2:20][O:21][CH2:22]Cl)([CH3:18])[CH3:17]>>[F:14][C:2]([F:1])([F:13])[C:3]1[N:4]([CH2:22][O:21][CH2:20][CH2:19][Si:16]([CH3:18])([CH3:17])[CH3:15])[CH:5]=[C:6]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:7]=1

Participants

3

Reactant 2

HCID 27242712-Chloromethyl 2-(trimethylsilyl)ethyl etherHCID 178469894HCID 178469894, compound

Product 1

HCID 70981359HCID 70981359, compound

Procedure

The title compound was prepared using the procedure described in Example 52(b) starting from ethyl 2-(trifluoromethyl)-1H-imidazole-4-carboxylate (9.5 mmol, 2 g) and SEM-Cl (11.5 mmol, 2.1 ml). Yield 1.9 g. 1H-NMR (400 MHz; CDCl3): δ −0.01 (s, 9H), 0.91 (t, 2H), 1.40 (t, 3H), 3.54 (t, 2H), 4.40 (q, 2H), 5.43 (s, 2H), 7.85 (s, 1H).

Sources & evidence

ORD record
ord-596deaada04c4ba682f2bd58d376c85c
Source dataset
uspto-grants-2014_12
Patent number
US08921378B2

Reaction notes

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