HCID 70981231, compound → HCID 70980874, compound

HRID 1409470Notes

Reaction equation

[CH2:1]([O:3][C:4]([C:7]1[N:8]([CH2:16][O:17][CH2:18][CH2:19][Si:20]([CH3:23])([CH3:22])[CH3:21])[CH:9]=[C:10]([C:12]([O:14]C)=[O:13])[N:11]=1)([CH3:6])[CH3:5])[CH3:2].C(OC(C1N(COCC[Si](C)(C)C)C=C(C(OCC)=O)N=1)(C)C)C>>[CH2:1]([O:3][C:4]([C:7]1[N:8]([CH2:16][O:17][CH2:18][CH2:19][Si:20]([CH3:21])([CH3:22])[CH3:23])[CH:9]=[C:10]([C:12]([OH:14])=[O:13])[N:11]=1)([CH3:5])[CH3:6])[CH3:2]

Participants

Reactant 2

HCID 70981231HCID 70981231, compound

HCID 70981651HCID 70981651, compound

Product 1

HCID 70980874HCID 70980874, compound

Procedure

The title compound was prepared using the procedure described in Example 58(e) starting from the mixture of methyl 2-(2-ethoxypropan-2-yl)-1-((2-(trimethyl-silyl)ethoxy)methyl)-1H-imidazole-4-carboxylate and ethyl 2-(2-ethoxypropan-2-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-4-carboxylate (90 mg). Yield 70 mg. 1H-NMR (400 MHz; DMSO-d6): δ −0.02 (s, 9H), 0.87 (t, 2H), 1.06 (t, 3H), 1.57 (s, 6H), 3.12 (q, 2H), 3.58 (t, 2H), 5.53 (s, 2H), 7.93 (s, 1H), 12.28 (bs, 1H).

Sources & evidence

ORD record: ord-c94bc8a5c8934fb0a55b9ed67b77192c
Source dataset: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08921378B2

Reaction notes

Loading…