HCID 70980814, compound → HCID 70981983, compound

HRID 1409472Notes

Reaction equation

[CH2:1]([O:3][CH:4]([C:6]1[N:7]([CH2:15][O:16][CH2:17][CH2:18][Si:19]([CH3:22])([CH3:21])[CH3:20])[CH:8]=[C:9]([C:11]([O:13]C)=[O:12])[N:10]=1)[CH3:5])[CH3:2].C(OC(C1N(COCC[Si](C)(C)C)C=C(C(OCC)=O)N=1)C)C>>[CH2:1]([O:3][CH:4]([C:6]1[N:7]([CH2:15][O:16][CH2:17][CH2:18][Si:19]([CH3:20])([CH3:21])[CH3:22])[CH:8]=[C:9]([C:11]([OH:13])=[O:12])[N:10]=1)[CH3:5])[CH3:2]

Participants

Reactant 2

HCID 70980814HCID 70980814, compound

HCID 70981263HCID 70981263, compound

Product 1

HCID 70981983HCID 70981983, compound

Procedure

The title compound was prepared using the procedure described in Example 58(e) starting from the mixture of methyl 2-(1-ethoxyethyl)-1-((2-(trimethylsilyl)-ethoxy)methyl)-1H-imidazole-4-carboxylate and ethyl 2-(1-ethoxyethyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-4-carboxylate (600 mg). Yield 370 mg. 1H-NMR (400 MHz; DMSO-d6): δ −0.01 (s, 9H), 0.86 (t, 2H), 1.08 (d, 3H), 1.45 (t, 3H), 3.41 (q, 2H), 3.50 (t, 2H), 4.71 (q, 1H), 5.42 (s, 2H), 7.92 (s, 1H), 12.13 (bs, 1H). LC-MS: [M+1]=315.12.

Sources & evidence

ORD record: ord-0d1e41672d674d879cb651cb364a310d
Source dataset: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08921378B2

Reaction notes

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