Trifluoroacetic acid → HCID 86689243, compound

HRID 1409507Notes

Reaction equation

Br[C:2]1[CH:3]=[C:4]2[C:15]3([C:23]4[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=4)[C:17]([NH2:24])=[N:16]3)[C:14]3[CH:13]=[C:12]([Cl:25])[N:11]=[CH:10][C:9]=3[O:8][C:5]2=[CH:6][CH:7]=1.[C:26]([OH:32])([C:28]([F:31])([F:30])[F:29])=[O:27]>>[F:29][C:28]([F:31])([F:30])[C:26]([OH:32])=[O:27].[Cl:25][C:12]1[N:11]=[CH:10][C:9]2[O:8][C:5]3[C:4]([C:15]4([C:23]5[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=5)[C:17]([NH2:24])=[N:16]4)[C:14]=2[CH:13]=1)=[CH:3][C:2]([C:26]1[C:28]([F:31])=[N:11][CH:10]=[CH:9][CH:14]=1)=[CH:7][CH:6]=3

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 86689244HCID 86689244, compound

Product 1

HCID 86689243HCID 86689243, compound

Procedure

The title compound was synthesized by procedures and steps analogous to those described in Example 5 above, but using 7-bromo-3-chlorospiro[chromeno[2,3-c]pyridine-5,1′-isoindol]-3′-amine in step 3. MS m/z=429.0 [M+H]+. Calculated for C24H14ClFN4OC2HF3O2: 542.87 (TFA salt).

Sources & evidence

ORD record: ord-560ac03a2b3345c8a25a25ed742094df
Source dataset: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08921363B2

Reaction notes

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