Trifluoroacetic acid → HCID 86689257, compound

HRID 1409518Notes

Reaction equation

Br[C:2]1[CH:3]=[C:4]2[C@@:15]3([C:23]4[C:18](=[N:19][CH:20]=[CH:21][CH:22]=4)[C:17]([NH2:24])=[N:16]3)[C:14]3[CH:13]=[C:12]([Cl:25])[N:11]=[C:10]([F:26])[C:9]=3[O:8][C:5]2=[CH:6][CH:7]=1.[C:27]([OH:33])([C:29]([F:32])([F:31])[F:30])=[O:28]>>[F:30][C:29]([F:32])([F:31])[C:27]([OH:33])=[O:28].[Cl:25][C:12]1[N:11]=[C:10]([F:26])[C:9]2[O:8][C:5]3[C:4]([C@@:15]4([C:23]5[C:18](=[N:19][CH:20]=[CH:21][CH:22]=5)[C:17]([NH2:24])=[N:16]4)[C:14]=2[CH:13]=1)=[CH:3][C:2]([C:27]1[C:29]([F:32])=[N:11][CH:10]=[CH:9][CH:14]=1)=[CH:7][CH:6]=3

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 86689259HCID 86689259, compound

Product 1

HCID 86689257HCID 86689257, compound

Procedure

The titled compound was synthesized by procedures and steps analogous to those described in Example 5 above, but using (S)-7-bromo-3-chloro-1-fluorospiro[chromeno[2,3-c]pyridine-5,5′-pyrrolo[3,4-b]pyridin]-7′-amine (17c-2) in step 3. MS m/z=448.0 [M+H]+. Calculated for C23H12ClF2N5OC2HF3O2: 561.85 (TFA salt).

Sources & evidence

ORD record: ord-f7ba30f2a1e24d5688cc83136c330763
Source dataset: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08921363B2

Reaction notes

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