反应详情

To a RBF was added 2-bromo-3-pyridinol (6.0 g, 34.5 mmol) and potassium carbonate (11.91 g, 86 mmol) in Acetone (50 mL). The suspension was stirred at ambient temperature for 30 min and then treated with the drop-wise addition of chloromethyl ethyl ether (3.34 mL, 36.7 mmol) via addition funnel. The mixture was stirred at ambient temperature overnight. The mixture was filtered and the filtrate partitioned between EtOAc and water. The combined organic layers were washed with water, saturated solution of sodium bicarbonate and brine, then dried over Mg2SO4 to afford 7.12 g of desired product as a clear oil which was used without further purification.

1. stirringThe mixture was stirred at ambient temperature overnight
2. filtrationThe mixture was filtered
3. customthe filtrate partitioned between EtOAc and water
4. washThe combined organic layers were washed with water, saturated solution of sodium bicarbonate and brine
5. dry with materialdried over Mg2SO4