4-Fluorobenzylamine → HCID 136377083, compound

HRID 1409568Notes

Reaction equation

[C:1]1([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][C:8]1[NH:9][C:10](=[O:19])[C:11]([OH:18])=[C:12]([C:14](OC)=[O:15])[N:13]=1.[F:26][C:27]1[CH:34]=[CH:33][C:30]([CH2:31][NH2:32])=[CH:29][CH:28]=1>>[F:26][C:27]1[CH:34]=[CH:33][C:30]([CH2:31][NH:32][C:14]([C:12]2[N:13]=[C:8]([CH2:7][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][C:1]=3[C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[NH:9][C:10](=[O:19])[C:11]=2[OH:18])=[O:15])=[CH:29][CH:28]=1

Participants

Reactant 2

HCID 673264-Fluorobenzylamine

HCID 136377081HCID 136377081, compound

Product 1

HCID 136377083HCID 136377083, compoundYield 18%

Procedure

The synthesis performed as in Example 21 using methyl 2-(biphenyl-2-ylmethyl)-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxylate (0.070 g, 208 μmol) and 4-fluorobenzylamine (0.5 ml; 4.38 mmol) to provide the title compound as an off-white solid (0.016 g; 18%). LCMS: m/z=430 (MH+).

Sources & evidence

ORD record: ord-333e2d8692bb40a5865196662db917be
Source dataset: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08921388B2

Reaction notes

Loading…