4-(Cyanomethyl)benzeneboronic acid → 2-(4-Cyanomethyl-phenyl)-pyrimidine-5-carboxylic acid cyclopropyl-piperidin-4-yl amide

HRID 1409691노트

반응식

HRID 1409691 반응식
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([N:14]([C:18]([C:20]2[CH:21]=[N:22][C:23](Cl)=[N:24][CH:25]=2)=[O:19])[CH:15]2[CH2:17][CH2:16]2)[CH2:10][CH2:9]1)=O)(C)(C)C.[C:27]([CH2:29][C:30]1[CH:35]=[CH:34][C:33](B(O)O)=[CH:32][CH:31]=1)#[N:28]>>[CH:15]1([N:14]([CH:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)[C:18]([C:20]2[CH:21]=[N:22][C:23]([C:33]3[CH:34]=[CH:35][C:30]([CH2:29][C:27]#[N:28])=[CH:31][CH:32]=3)=[N:24][CH:25]=2)=[O:19])[CH2:16][CH2:17]1

참가 물질

3

반응물 2

HCID 27733424-(Cyanomethyl)benzeneboronic acidHCID 866861524-[(2-Chloro-pyrimidine-5-carbonyl)-cyclopropyl-amino]-piperidine-1-carboxylic acid tert-butyl ester

생성물 1

HCID 710937352-(4-Cyanomethyl-phenyl)-pyrimidine-5-carboxylic acid cyclopropyl-piperidin-4-yl amide

실험 절차

The title compound is prepared from 4-[(2-chloro-pyrimidine-5-carbonyl)-cyclopropyl-amino]-piperidine-1-carboxylic acid tert-butyl ester and (4-cyanomethylphenyl)boronic acid following a procedure analogous to that described in Intermediate 6. LC (method 4): tR=0.85 min; Mass spectrum (ESI+): m/z=362 [M+H]+.

출처 및 근거

ORD 기록
ord-62bd87adef8b409da3c9566f9f1d1432
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08921398B2

반응 노트

불러오는 중…