HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Cyanomethyl)benzeneboronic acid → 2-(4-Cyanomethyl-phenyl)-pyrimidine-5-carboxylic acid cyclopropyl-piperidin-4-yl amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Cyanomethyl)benzeneboronic acid | HCID 2773342 | — |
| Reactant | 4-[(2-Chloro-pyrimidine-5-carbonyl)-cyclopropyl-amino]-piperidine-1-carboxylic acid tert-butyl ester | HCID 86686152 | — |
| Product | 2-(4-Cyanomethyl-phenyl)-pyrimidine-5-carboxylic acid cyclopropyl-piperidin-4-yl amide | HCID 71093735 | — |
Reaction Steps
The title compound is prepared from 4-[(2-chloro-pyrimidine-5-carbonyl)-cyclopropyl-amino]-piperidine-1-carboxylic acid tert-butyl ester and (4-cyanomethylphenyl)boronic acid following a procedure analogous to that described in Intermediate 6. LC (method 4): tR=0.85 min; Mass spectrum (ESI+): m/z=362 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08921398B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-62bd87adef8b409da3c9566f9f1d1432 |
| Source note | uspto-grants-2014_12 |