Trifluoroacetic acid → N-cyclopropyl-2-(1H-imidazol-1-yl)-N-(piperidin-4-yl)pyrimidine-5-carboxamide

HRID 1409697Notes

Reaction equation

HRID 1409697 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([N:14]([CH:28]2[CH2:30][CH2:29]2)[C:15]([C:17]2[CH:18]=[N:19][C:20]([N:23]3[CH:27]=[CH:26][N:25]=[CH:24]3)=[N:21][CH:22]=2)=[O:16])[CH2:10][CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[CH:28]1([N:14]([CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[C:15]([C:17]2[CH:22]=[N:21][C:20]([N:23]3[CH:27]=[CH:26][N:25]=[CH:24]3)=[N:19][CH:18]=2)=[O:16])[CH2:29][CH2:30]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 710937544-[Cyclopropyl-(2-imidazol-1-yl-pyrimidine-5-carbonyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 71093743N-cyclopropyl-2-(1H-imidazol-1-yl)-N-(piperidin-4-yl)pyrimidine-5-carboxamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound is prepared from 4-[cyclopropyl-(2-imidazol-1-yl-pyrimidine-5-carbonyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester by treatment with trifluoroacetic acid in dichloromethane. LC (method 10): tR=0.68 min; Mass spectrum (ESI+): m/z=313 [M+H]+.

Sources & evidence

ORD record
ord-e3603d533eb84f27b457569e92b2c534
Source dataset
uspto-grants-2014_12
Patent number
US08921398B2

Reaction notes

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