HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → N-cyclopropyl-2-(4-(methylsulfonyl)phenyl)-N-(piperidin-4-yl)pyrimidine-5-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 4-{Cyclopropyl-[2-(4-methanesulfonyl-phenyl)-pyrimidine-5-carbonyl]-amino}-piperidine-1-carboxylic acid tert-butyl ester | HCID 71093732 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-cyclopropyl-2-(4-(methylsulfonyl)phenyl)-N-(piperidin-4-yl)pyrimidine-5-carboxamide | HCID 71093749 | — |
Reaction Steps
The title compound is prepared from 4-{cyclopropyl-[2-(4-methanesulfonyl-phenyl)-pyrimidine-5-carbonyl]-amino}-piperidine-1-carboxylic acid tert-butyl ester by treatment with trifluoroacetic acid in dichloromethane. LC (method 10): tR=1.20 min; Mass spectrum (ESI+): m/z=401 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08921398B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-771f788754c246199e4eda83e33d91bf |
| Source note | uspto-grants-2014_12 |