Trifluoroacetic acid → N-cyclopropyl-2-(4-(methylsulfonyl)phenyl)-N-(piperidin-4-yl)pyrimidine-5-carboxamide

HRID 1409699Notes

Reaction equation

HRID 1409699 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([N:14]([CH:33]2[CH2:35][CH2:34]2)[C:15]([C:17]2[CH:18]=[N:19][C:20]([C:23]3[CH:28]=[CH:27][C:26]([S:29]([CH3:32])(=[O:31])=[O:30])=[CH:25][CH:24]=3)=[N:21][CH:22]=2)=[O:16])[CH2:10][CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[CH:33]1([N:14]([CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[C:15]([C:17]2[CH:22]=[N:21][C:20]([C:23]3[CH:28]=[CH:27][C:26]([S:29]([CH3:32])(=[O:31])=[O:30])=[CH:25][CH:24]=3)=[N:19][CH:18]=2)=[O:16])[CH2:35][CH2:34]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 710937324-{Cyclopropyl-[2-(4-methanesulfonyl-phenyl)-pyrimidine-5-carbonyl]-amino}-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 71093749N-cyclopropyl-2-(4-(methylsulfonyl)phenyl)-N-(piperidin-4-yl)pyrimidine-5-carboxamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound is prepared from 4-{cyclopropyl-[2-(4-methanesulfonyl-phenyl)-pyrimidine-5-carbonyl]-amino}-piperidine-1-carboxylic acid tert-butyl ester by treatment with trifluoroacetic acid in dichloromethane. LC (method 10): tR=1.20 min; Mass spectrum (ESI+): m/z=401 [M+H]+.

Sources & evidence

ORD record
ord-771f788754c246199e4eda83e33d91bf
Source dataset
uspto-grants-2014_12
Patent number
US08921398B2

Reaction notes

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