2-Methylimidazole → HCID 71093756, compound

HRID 1409700Notes

Reaction equation

HRID 1409700 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([N:14]([C:18]([C:20]2[CH:21]=[N:22][C:23](Cl)=[N:24][CH:25]=2)=[O:19])[CH:15]2[CH2:17][CH2:16]2)[CH2:10][CH2:9]1)=O)(C)(C)C.[CH3:27][C:28]1[NH:29][CH:30]=[CH:31][N:32]=1>>[CH:15]1([N:14]([CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[C:18]([C:20]2[CH:25]=[N:24][C:23]([N:29]3[CH:30]=[CH:31][N:32]=[C:28]3[CH3:27])=[N:22][CH:21]=2)=[O:19])[CH2:16][CH2:17]1

Participants

3

Reactant 2

HCID 127492-MethylimidazoleHCID 866861524-[(2-Chloro-pyrimidine-5-carbonyl)-cyclopropyl-amino]-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 71093756HCID 71093756, compound

Procedure

The title compound is prepared from 4-[(2-chloro-pyrimidine-5-carbonyl)-cyclopropyl-amino]-piperidine-1-carboxylic acid tert-butyl ester and 2-methyl-1H-imidazole following procedures analogous to those described in Intermediate 16 and Intermediate 17. LC (method 10): tR=0.56 min; Mass spectrum (ESI+): m/z=327 [M+H]+.

Sources & evidence

ORD record
ord-7109d1fa1e604a01b2083c72a5951018
Source dataset
uspto-grants-2014_12
Patent number
US08921398B2

Reaction notes

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