2-Ethylimidazole → 2-(2-Ethyl-imidazol-1-yl)-pyrimidine-5-carboxylic acid cyclopropyl-piperidin-4-yl-amide

HRID 1409701Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1409701
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([N:14]([C:18]([C:20]2[CH:21]=[N:22][C:23](Cl)=[N:24][CH:25]=2)=[O:19])[CH:15]2[CH2:17][CH2:16]2)[CH2:10][CH2:9]1)=O)(C)(C)C.[CH2:27]([C:29]1[NH:30][CH:31]=[CH:32][N:33]=1)[CH3:28]>>[CH:15]1([N:14]([CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[C:18]([C:20]2[CH:25]=[N:24][C:23]([N:30]3[CH:31]=[CH:32][N:33]=[C:29]3[CH2:27][CH3:28])=[N:22][CH:21]=2)=[O:19])[CH2:17][CH2:16]1

Komponenten

3

Edukt 2

HCID 661302-EthylimidazoleHCID 866861524-[(2-Chloro-pyrimidine-5-carbonyl)-cyclopropyl-amino]-piperidine-1-carboxylic acid tert-butyl ester

Produkt 1

HCID 710937462-(2-Ethyl-imidazol-1-yl)-pyrimidine-5-carboxylic acid cyclopropyl-piperidin-4-yl-amide

Versuchsvorschrift

The title compound is prepared from 4-[(2-chloro-pyrimidine-5-carbonyl)-cyclopropyl-amino]-piperidine-1-carboxylic acid tert-butyl ester and 2-ethyl-1H-imidazole following procedures analogous to those described in Intermediate 16 and Intermediate 17. LC (method 10): tR=0.56 min; Mass spectrum (ESI+): m/z=341 [M+H]+.

Quellen und Nachweise

ORD-Eintrag
ord-6203249d46cc4865afb99ca265aacf93
Quelldatensatz
uspto-grants-2014_12
Patentnummer
US08921398B2

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