HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Ethylimidazole → 2-(2-Ethyl-imidazol-1-yl)-pyrimidine-5-carboxylic acid cyclopropyl-piperidin-4-yl-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Ethylimidazole | HCID 66130 | — |
| Reactant | 4-[(2-Chloro-pyrimidine-5-carbonyl)-cyclopropyl-amino]-piperidine-1-carboxylic acid tert-butyl ester | HCID 86686152 | — |
| Product | 2-(2-Ethyl-imidazol-1-yl)-pyrimidine-5-carboxylic acid cyclopropyl-piperidin-4-yl-amide | HCID 71093746 | — |
Reaction Steps
The title compound is prepared from 4-[(2-chloro-pyrimidine-5-carbonyl)-cyclopropyl-amino]-piperidine-1-carboxylic acid tert-butyl ester and 2-ethyl-1H-imidazole following procedures analogous to those described in Intermediate 16 and Intermediate 17. LC (method 10): tR=0.56 min; Mass spectrum (ESI+): m/z=341 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08921398B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-6203249d46cc4865afb99ca265aacf93 |
| Source note | uspto-grants-2014_12 |