Sodium Hydroxide → 1415836-74-6

HRID 1409713Notes

Reaction equation

HRID 1409713 reaction equation
C([O:3][C:4]([C:6]1[CH:10]=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([C:17]#[N:18])=[CH:13][C:12]=2[F:19])[O:8][N:7]=1)=[O:5])C.[OH-].[Na+]>O1CCCC1>[C:17]([C:14]1[CH:15]=[CH:16][C:11]([C:9]2[O:8][N:7]=[C:6]([C:4]([OH:5])=[O:3])[CH:10]=2)=[C:12]([F:19])[CH:13]=1)#[N:18]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 710937335-(4-Cyano-2-fluoro-phenyl)-isoxazole-3-carboxylic acid ethyl ester

Product 1

HCID 710937371415836-74-6

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The title compound is prepared from 5-(4-cyano-2-fluoro-phenyl)-isoxazole-3-carboxylic acid ethyl ester by treatment with aqueous NaOH solution in tetrahydrofuran. LC (method 18): tR=0.32 min; Mass spectrum (EI): m/z=232 [M]+.

Sources & evidence

ORD record
ord-8aa74005055e45ecb16fb6485fe705c1
Source dataset
uspto-grants-2014_12
Patent number
US08921398B2

Reaction notes

Loading…