Triacetoxyperiodinane → 1-(5-Ethyl-pyrazin-2-yl)-piperidin-4-one

HRID 1409719Notes

Reaction equation

HRID 1409719 reaction equation
[CH2:1]([C:3]1[N:4]=[CH:5][C:6]([N:9]2[CH2:14][CH2:13][CH:12]([OH:15])[CH2:11][CH2:10]2)=[N:7][CH:8]=1)[CH3:2].CC(OI1(OC(C)=O)(OC(C)=O)OC(=O)C2C=CC=CC1=2)=O>ClCCl>[CH2:1]([C:3]1[N:4]=[CH:5][C:6]([N:9]2[CH2:14][CH2:13][C:12](=[O:15])[CH2:11][CH2:10]2)=[N:7][CH:8]=1)[CH3:2]

Participants

4

Reactant 2

HCID 159087TriacetoxyperiodinaneHCID 67608386HCID 67608386, compound

Product 1

HCID 682900371-(5-Ethyl-pyrazin-2-yl)-piperidin-4-one

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound is prepared from 1-(5-ethyl-pyrazin-2-yl)-piperidin-4-ol by oxidation with Dess-Martin periodinane in dichloromethane at room temperature. LC (method 7): tR=0.73 min; Mass spectrum (ESI+): m/z=206 [M+H]+.

Sources & evidence

ORD record
ord-5d7195145e374b18957f84173dafc4dd
Source dataset
uspto-grants-2014_12
Patent number
US08921398B2

Reaction notes

Loading…