Piperidin-4-ol → HCID 66868496, compound

HRID 1409722Notes

Reaction equation

HRID 1409722 reaction equation
Br[C:2]1[CH:7]=[N:6][C:5]([CH3:8])=[CH:4][N:3]=1.[OH:9][CH:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1>>[CH3:8][C:5]1[N:6]=[CH:7][C:2]([N:13]2[CH2:14][CH2:15][CH:10]([OH:9])[CH2:11][CH2:12]2)=[N:3][CH:4]=1

Participants

3

Reactant 2

HCID 79341Piperidin-4-olHCID 224193462-Bromo-5-methylpyrazine

Product 1

HCID 66868496HCID 66868496, compound

Procedure

The title compound is prepared from 2-bromo-5-methyl-pyrazine and 4-hydroxy-piperidine following a procedure analogous to that described in Intermediate 47. LC (method 8): tR=0.94 min; Mass spectrum (ESI+): m/z=194 [M+H]+.

Sources & evidence

ORD record
ord-f7320ddf31d2451a86e48a99fbdb5946
Source dataset
uspto-grants-2014_12
Patent number
US08921398B2

Reaction notes

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