Hydrochloric Acid → HCID 58377077, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of methyl 5-chloropyrazine-2-carboxylate (0.75 g), K2CO3 (1.8 g) and 1H-1,2,4-triazole (1.2 g) in N,N-dimethylformamide (6 mL) is heated to 100° C. overnight. Analysis of the crude mixture by LCMS shows saponified product. The product is acidified with 1N HCl and the precipitate is filtered and washed with water and diethyl ether to afford the title compound. LC (method 20): tR=1.06 min; Mass spectrum (APCI): m/z=192 [M+H]+.

Provenance & Evidence