Hydrochloric Acid → HCID 58377077, compound

HRID 1409726Notes

Reaction equation

HRID 1409726 reaction equation
Cl[C:2]1[N:3]=[CH:4][C:5]([C:8]([O:10]C)=[O:9])=[N:6][CH:7]=1.C([O-])([O-])=O.[K+].[K+].[NH:18]1[CH:22]=[N:21][CH:20]=[N:19]1.Cl>CN(C)C=O>[N:18]1([C:2]2[N:3]=[CH:4][C:5]([C:8]([OH:10])=[O:9])=[N:6][CH:7]=2)[CH:22]=[N:21][CH:20]=[N:19]1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 92571H-1,2,4-TriazoleHCID 11430Potassium CarbonateHCID 406081Methyl 5-chloropyrazine-2-carboxylate

Product 1

HCID 58377077HCID 58377077, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of methyl 5-chloropyrazine-2-carboxylate (0.75 g), K2CO3 (1.8 g) and 1H-1,2,4-triazole (1.2 g) in N,N-dimethylformamide (6 mL) is heated to 100° C. overnight. Analysis of the crude mixture by LCMS shows saponified product. The product is acidified with 1N HCl and the precipitate is filtered and washed with water and diethyl ether to afford the title compound. LC (method 20): tR=1.06 min; Mass spectrum (APCI): m/z=192 [M+H]+.

Workup

  1. filtrationthe precipitate is filtered
  2. washwashed with water and diethyl ether

Sources & evidence

ORD record
ord-f649a76f4235421d9b3de231585dac89
Source dataset
uspto-grants-2014_12
Patent number
US08921398B2

Reaction notes

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