HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 71112312, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3,4-Difluorobenzonitrile | HCID 587203 | — |
| Reactant | HCID 178433052 | HCID 178433052 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 71112312 | HCID 71112312 | — |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
A mixture of 2-methyl-1H-imidazole-4-carboxylic acid (400 mg), 4-fluoro-3-fluorobenzonitrile (0.53 g), and K2CO3 (1.3 g) in N,N-dimethylformamide (6 mL) is heated to 100° C. for 30 minutes in a microwave. The crude product is purified by HPLC. LC (method 20): tR=1.24 min; Mass spectrum (APCI): m/z=246 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08921398B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-86153bf94bcd41539cca858609bb97b6 |
| Source note | uspto-grants-2014_12 |