Potassium Carbonate → HCID 71112312, compound

HRID 1409732Notes

Reaction equation

HRID 1409732 reaction equation
[CH3:1][C:2]1[NH:3][CH:4]=[C:5]([C:7]([OH:9])=[O:8])[N:6]=1.F[C:11]1[CH:18]=[CH:17][C:14]([C:15]#[N:16])=[CH:13][C:12]=1[F:19].C([O-])([O-])=O.[K+].[K+]>CN(C)C=O>[C:15]([C:14]1[CH:17]=[CH:18][C:11]([N:3]2[CH:4]=[C:5]([C:7]([OH:9])=[O:8])[N:6]=[C:2]2[CH3:1])=[C:12]([F:19])[CH:13]=1)#[N:16]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 5872033,4-DifluorobenzonitrileHCID 178433052HCID 178433052, compound

Product 1

HCID 71112312HCID 71112312, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 2-methyl-1H-imidazole-4-carboxylic acid (400 mg), 4-fluoro-3-fluorobenzonitrile (0.53 g), and K2CO3 (1.3 g) in N,N-dimethylformamide (6 mL) is heated to 100° C. for 30 minutes in a microwave. The crude product is purified by HPLC. LC (method 20): tR=1.24 min; Mass spectrum (APCI): m/z=246 [M+H]+.

Workup

  1. customThe crude product is purified by HPLC

Sources & evidence

ORD record
ord-86153bf94bcd41539cca858609bb97b6
Source dataset
uspto-grants-2014_12
Patent number
US08921398B2

Reaction notes

Loading…