2-(Pyridin-4-yl)pyrimidine-5-carboxylic acid → 2-Pyridin-4-yl-pyrimidine-5-carboxylic acid cyclopropyl-[1-(3-phenyl-[1,2,4]oxadiazol-5-yl)-piperidin-4-yl]-amide

HRID 1409751Notes

Reaction equation

HRID 1409751 reaction equation
[CH:1]1([NH:4][CH:5]2[CH2:10][CH2:9][N:8]([C:11]3[O:15][N:14]=[C:13]([C:16]4[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=4)[N:12]=3)[CH2:7][CH2:6]2)[CH2:3][CH2:2]1.[N:22]1[CH:27]=[CH:26][C:25]([C:28]2[N:33]=[CH:32][C:31]([C:34](O)=[O:35])=[CH:30][N:29]=2)=[CH:24][CH:23]=1>>[CH:1]1([N:4]([CH:5]2[CH2:6][CH2:7][N:8]([C:11]3[O:15][N:14]=[C:13]([C:16]4[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=4)[N:12]=3)[CH2:9][CH2:10]2)[C:34]([C:31]2[CH:32]=[N:33][C:28]([C:25]3[CH:26]=[CH:27][N:22]=[CH:23][CH:24]=3)=[N:29][CH:30]=2)=[O:35])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 227102132-(Pyridin-4-yl)pyrimidine-5-carboxylic acidHCID 68289604N-cyclopropyl-1-(3-phenyl-1,2,4-oxadiazol-5-yl)piperidin-4-amine

Product 1

HCID 711120082-Pyridin-4-yl-pyrimidine-5-carboxylic acid cyclopropyl-[1-(3-phenyl-[1,2,4]oxadiazol-5-yl)-piperidin-4-yl]-amide

Procedure

The title compound is prepared from cyclopropyl-[1-(3-phenyl-[1,2,4]oxadiazol-5-yl)-piperidin-4-yl]-amine and 2-pyridin-4-yl-pyrimidine-5-carboxylic acid following a procedure analogous to that described in Example 1. LC (method 2): tR=1.76 min; Mass spectrum (ESI+): m/z=468 [M+H]+.

Sources & evidence

ORD record
ord-4d2e31dc00f844ffbbb3f982b4dbdf31
Source dataset
uspto-grants-2014_12
Patent number
US08921398B2

Reaction notes

Loading…