2-Chloro-5-ethylpyrimidine → 2-Imidazol-1-yl-pyrimidine-5-carboxylic acid cyclopropyl-[1-(5-ethyl-pyrimidin-2-yl)-piperidin-4-yl]-amide

HRID 1409760Notes

Reaction equation

HRID 1409760 reaction equation
[CH:1]1([N:4]([CH:18]2[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)[C:5]([C:7]2[CH:8]=[N:9][C:10]([N:13]3[CH:17]=[CH:16][N:15]=[CH:14]3)=[N:11][CH:12]=2)=[O:6])[CH2:3][CH2:2]1.Cl[C:25]1[N:30]=[CH:29][C:28]([CH2:31][CH3:32])=[CH:27][N:26]=1>>[CH:1]1([N:4]([CH:18]2[CH2:23][CH2:22][N:21]([C:25]3[N:30]=[CH:29][C:28]([CH2:31][CH3:32])=[CH:27][N:26]=3)[CH2:20][CH2:19]2)[C:5]([C:7]2[CH:12]=[N:11][C:10]([N:13]3[CH:17]=[CH:16][N:15]=[CH:14]3)=[N:9][CH:8]=2)=[O:6])[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 35727632-Chloro-5-ethylpyrimidineHCID 71093743N-cyclopropyl-2-(1H-imidazol-1-yl)-N-(piperidin-4-yl)pyrimidine-5-carboxamide

Product 1

HCID 866861682-Imidazol-1-yl-pyrimidine-5-carboxylic acid cyclopropyl-[1-(5-ethyl-pyrimidin-2-yl)-piperidin-4-yl]-amide

Procedure

The title compound is prepared from 2-imidazol-1-yl-pyrimidine-5-carboxylic acid cyclopropyl-piperidin-4-yl-amide and 2-chloro-5-ethylpyrimidine following a procedure analogous to that described in Example 3. LC (method 10): tR=1.40 min; Mass spectrum (ESI+): m/z=419 [M+H]+.

Sources & evidence

ORD record
ord-c2014ecdb078459386968baa97b83526
Source dataset
uspto-grants-2014_12
Patent number
US08921398B2

Reaction notes

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