2-Chloro-5-ethylpyrimidine → 2-(4-Methanesulfonyl-phenyl)-pyrimidine-5-carboxylic acid cyclopropyl-[1-(5-ethyl-pyrimidin-2-yl)-piperidin-4-yl]-amide

HRID 1409761Notes

Reaction equation

HRID 1409761 reaction equation
[CH:1]1([N:4]([CH:23]2[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]2)[C:5]([C:7]2[CH:8]=[N:9][C:10]([C:13]3[CH:18]=[CH:17][C:16]([S:19]([CH3:22])(=[O:21])=[O:20])=[CH:15][CH:14]=3)=[N:11][CH:12]=2)=[O:6])[CH2:3][CH2:2]1.Cl[C:30]1[N:35]=[CH:34][C:33]([CH2:36][CH3:37])=[CH:32][N:31]=1>>[CH:1]1([N:4]([CH:23]2[CH2:28][CH2:27][N:26]([C:30]3[N:35]=[CH:34][C:33]([CH2:36][CH3:37])=[CH:32][N:31]=3)[CH2:25][CH2:24]2)[C:5]([C:7]2[CH:12]=[N:11][C:10]([C:13]3[CH:18]=[CH:17][C:16]([S:19]([CH3:22])(=[O:21])=[O:20])=[CH:15][CH:14]=3)=[N:9][CH:8]=2)=[O:6])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 35727632-Chloro-5-ethylpyrimidineHCID 71093749N-cyclopropyl-2-(4-(methylsulfonyl)phenyl)-N-(piperidin-4-yl)pyrimidine-5-carboxamide

Product 1

HCID 711123182-(4-Methanesulfonyl-phenyl)-pyrimidine-5-carboxylic acid cyclopropyl-[1-(5-ethyl-pyrimidin-2-yl)-piperidin-4-yl]-amide

Procedure

The title compound is prepared from 2-(4-methanesulfonyl-phenyl)-pyrimidine-5-carboxylic acid cyclopropyl-piperidin-4-yl-amide and 2-chloro-5-ethylpyrimidine following a procedure analogous to that described in Example 3. LC (method 10): tR=1.80 min; Mass spectrum (ESI+): m/z=507 [M+H]+.

Sources & evidence

ORD record
ord-4eea0900e59e4a2992a2e0cbc7b06084
Source dataset
uspto-grants-2014_12
Patent number
US08921398B2

Reaction notes

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