2-Chloro-5-ethylpyrimidine → 2-(4-Methanesulfonyl-phenyl)-pyrimidine-5-carboxylic acid cyclopropyl-[1-(5-ethyl-pyrimidin-2-yl)-piperidin-4-yl]-amide

Participants

Role	Name	HCID	Charge
Reactant	2-Chloro-5-ethylpyrimidine	HCID 3572763	—
Reactant	N-cyclopropyl-2-(4-(methylsulfonyl)phenyl)-N-(piperidin-4-yl)pyrimidine-5-carboxamide	HCID 71093749	—
Product	2-(4-Methanesulfonyl-phenyl)-pyrimidine-5-carboxylic acid cyclopropyl-[1-(5-ethyl-pyrimidin-2-yl)-piperidin-4-yl]-amide	HCID 71112318	—

Reaction Steps

The title compound is prepared from 2-(4-methanesulfonyl-phenyl)-pyrimidine-5-carboxylic acid cyclopropyl-piperidin-4-yl-amide and 2-chloro-5-ethylpyrimidine following a procedure analogous to that described in Example 3. LC (method 10): tR=1.80 min; Mass spectrum (ESI+): m/z=507 [M+H]+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08921398B2
Source dataset	uspto-grants-2014_12
ORD ID	ord-4eea0900e59e4a2992a2e0cbc7b06084
Source note	uspto-grants-2014_12