N-methylpropyn-2-ylamine → HCID 25211812, compound

HRID 1409837Notes

Reaction equation

HRID 1409837 reaction equation
[F:1][C:2]([F:18])([F:17])[C:3]1[O:7][N:6]=[C:5]([C:8]2[S:12][C:11]([C:13]([OH:15])=O)=[CH:10][CH:9]=2)[C:4]=1[CH3:16].[CH3:19][NH:20][CH2:21][C:22]#[CH:23]>>[CH3:19][N:20]([CH2:21][C:22]#[CH:23])[C:13]([C:11]1[S:12][C:8]([C:5]2[C:4]([CH3:16])=[C:3]([C:2]([F:1])([F:18])[F:17])[O:7][N:6]=2)=[CH:9][CH:10]=1)=[O:15]

Participants

3

Reactant 2

HCID 96160N-methylpropyn-2-ylamineHCID 252109975-(4-Methyl-5-trifluoromethyl-isoxazol-3-yl)-thiophene-2-carboxylic acid

Product 1

HCID 25211812HCID 25211812, compound

Procedure

Prepared from 5-(5-Trifluoromethyl-4-methyl-isoxazol-3-yl)-thiophene-2-carboxylic acid and N-methyl propargylamine by the method described in Example 2 method B. Colorless solid (128 mg, 98%). 1H NMR (CDCl3) 2.37 (d, J=1.8, 3H), 3.28 (br s, 3H), 4.34 (br s, 2H), 7.48 (d, J=3.5, 1H), 7.51 (br d, 1H). 19F NMR −63.13. LC/MS 6.36 min, [M+1]+ 329.

Workup

  1. customLC/MS 6.36 min, [M+1]+ 329

Sources & evidence

ORD record
ord-f787b99b84934201be143e0804756a63
Source dataset
uspto-grants-2014_12
Patent number
US08921399B2

Reaction notes

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