N-methylpropyn-2-ylamine → HCID 25211812, compound

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Reaction Steps

Prepared from 5-(5-Trifluoromethyl-4-methyl-isoxazol-3-yl)-thiophene-2-carboxylic acid and N-methyl propargylamine by the method described in Example 2 method B. Colorless solid (128 mg, 98%). 1H NMR (CDCl3) 2.37 (d, J=1.8, 3H), 3.28 (br s, 3H), 4.34 (br s, 2H), 7.48 (d, J=3.5, 1H), 7.51 (br d, 1H). 19F NMR −63.13. LC/MS 6.36 min, [M+1]+ 329.

Provenance & Evidence