3-Methyl-2-butenoic acid → HCID 178447384, compound

HRID 1409912Notes

Reaction equation

HRID 1409912 reaction equation
Cl.Cl.[O:3]1[C:8]2=[CH:9][CH:10]=[CH:11][C:7]2=[CH:6][C:5]([CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][N:13]2[CH2:18][CH2:19][C@H:20]2[CH2:25][CH2:24][C@H:23]([NH2:26])[CH2:22][CH2:21]2)=[CH:4]1.[CH3:27][C:28]([CH3:33])=[CH:29][C:30](O)=[O:31]>>[O:3]1[C:8]2=[CH:9][CH:10]=[CH:11][C:7]2=[CH:6][C:5]([CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][N:13]2[CH2:18][CH2:19][C@H:20]2[CH2:21][CH2:22][C@H:23]([NH:26][C:30](=[O:31])[CH:29]=[C:28]([CH3:33])[CH3:27])[CH2:24][CH2:25]2)=[CH:4]1

Participants

3

Reactant 2

HCID 109313-Methyl-2-butenoic acidHCID 178478713HCID 178478713, compound2×

Product 1

HCID 178447384HCID 178447384, compound

Procedure

The title compound, off-white solid (83 mg, 81%), MS (ISP) m/z=409.4 [(M+H)+], mp 147° C., was prepared in accordance with the general method of example 1 from trans-4-[2-(4-benzofuran-3-yl-piperidin-1-yl)-ethyl]-cyclohexylamine dihydrochloride (intermediate A) (100 mg, 0.25 mmol) and 3-methyl-but-2-enoic acid.

Sources & evidence

ORD record
ord-b91bca6de32a4558ae7515e7c706a17e
Source dataset
uspto-grants-2014_12
Patent number
US08921397B2

Reaction notes

Loading…