(1,1'-Biphenyl)-4-carboxylic acid → HCID 178523639, compound

HRID 1409922Notes

Reaction equation

HRID 1409922 reaction equation
Cl.Cl.[O:3]1[C:8]2=[CH:9][CH:10]=[CH:11][C:7]2=[CH:6][C:5]([CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][N:13]2[CH2:18][CH2:19][C@H:20]2[CH2:25][CH2:24][C@H:23]([NH2:26])[CH2:22][CH2:21]2)=[CH:4]1.[C:27]1([C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)[CH:32]=[CH:31][C:30]([C:33](O)=[O:34])=[CH:29][CH:28]=1>>[O:3]1[C:8]2=[CH:9][CH:10]=[CH:11][C:7]2=[CH:6][C:5]([CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][N:13]2[CH2:18][CH2:19][C@H:20]2[CH2:21][CH2:22][C@H:23]([NH:26][C:33]([C:30]3[CH:31]=[CH:32][C:27]([C:36]4[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=4)=[CH:28][CH:29]=3)=[O:34])[CH2:24][CH2:25]2)=[CH:4]1

Participants

3

Reactant 2

HCID 66724(1,1'-Biphenyl)-4-carboxylic acidHCID 178478713HCID 178478713, compound2×

Product 1

HCID 178523639HCID 178523639, compound

Procedure

The title compound, yellow solid (119 mg, 94%), MS (ISP) m/z=507.3 [(M+H)+], mp 235° C., was prepared in accordance with the general method of example 1 from trans-4-[2-(4-benzofuran-3-yl-piperidin-1-yl)-ethyl]-cyclohexylamine dihydrochloride (intermediate A) (100 mg, 0.25 mmol) and biphenyl-4-carboxylic acid.

Sources & evidence

ORD record
ord-fb54f8ed45f1436d9515b1202847c0f0
Source dataset
uspto-grants-2014_12
Patent number
US08921397B2

Reaction notes

Loading…